Automated sample preparation for dioxin entails a combination of extraction and clean-up processes for getting rid of interfering substances and concentrate the analytes of interest. Using solid-phase extraction (SPE) in conjunction with a liquid handling system is a typical technique for automating sample preparation. The majority of automated sample preparation processes traditionally include liquid handling, which use robotics to dispense and gather precise volumes of liquid for purposes like adding reagents or washing samples. Automated sample preparation for dioxin approaches employs gas chromatography (GC) with high resolution mass spectrometry (HRMS) detection for the analytical component.